Friday, December 28, 2012

Journal of Medical Case Reports | Abstract | Cancer of the prostate ...

Open Access Case report

Innocent Lule Segamwenge, Nuru Kaddu Mgori, Safia AbdallahYussuf, Celia Nantume Mukulu, Philip Nakangombe, Paul Kioko Ngalyuka and Fred Kidaaga

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Journal of Medical Case Reports 2012, 6:425?doi:10.1186/1752-1947-6-425

Published: 28 December 2012

Abstract (provisional)

Introduction

Prostate cancer is the second most common cancer in men and the fifth most common cancer worldwide. In the USA it is more common in African-American men than in Caucasian men. Prostate cancer frequently metastasizes to bone and the lesions appear osteoblastic on radiographs. Presentation with diffuse osteolytic bone lesions is rare. We describe an unusual presentation of metastatic prostate cancer with diffuse osteolytic bone lesions.

Case presentation

A 65-year-old Namibian man presented with anemia, thrombocytopenia and worsening back pains. In addition he had complaints of effort intolerance, palpitations, dysuria and mild symptoms of bladder outlet obstruction. On examination he was found to be anemic, had a swollen tender right shoulder joint and spine tenderness to percussion. On digital rectal examination he had asymmetrical enlargement of the prostate which felt nodular and hard with diffuse firmness in some parts. His prostate-specific antigen was greater than 100ng/mL and he had diffuse osteolytic lesions involving the right humerus, and all vertebral, femur and pelvic bones. His screen for multiple myeloma was negative and the prostate biopsy confirmed prostate cancer.

Conclusion

Prostate cancer rarely presents with diffuse osteolytic bone lesions and should be considered in the differential diagnosis when evaluating male patients with osteolytic bone lesions.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Source: http://www.jmedicalcasereports.com/content/6/1/425

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